Premier League Matchday 4 Predictions

September 12, 2025 Aksel Kryhlmand

As the 2025/26 Premier League season continues, the Opta supercomputer has crunched the numbers once again. From fiery derbies to must-win matchups, we take you through all ten fixtures, ranked from the most unpredictable to the most lopsided, and preview each clash in eight to ten lines of expert insight and context.

10. West Ham vs Tottenham

Tottenham win, 41,8% · Draw, 25,5% · West Ham win, 32,7%

This London derby is shaping up to be a tight one. Spurs are slight favorites, but history is not on their side, they haven't won away to West Ham since 2019. Ange Postecoglou's side are looking to bounce back from their first defeat of the campaign, while West Ham grabbed their first win last weekend. The last three matches at the London Stadium have ended 1,1, and another draw wouldn’t be a surprise. This could go either way.

9. Brentford vs Chelsea

Chelsea win, 44,1% · Draw, 25,1% · Brentford win, 30,8%

Chelsea aim to keep their early season momentum alive as they face Brentford in yet another London derby. The Blues are chasing a third straight league win and have tightened up defensively under Enzo Maresca. Brentford have a strong home record lately, but they'll need to break down one of the Premier League’s most disciplined back lines. The odds lean toward Chelsea, but this could be a tense affair.

8. Everton vs Aston Villa

Aston Villa win, 39,6% · Draw, 25,9% · Everton win, 34,5%

This is a battle between a resurgent Everton and a struggling Aston Villa. The Toffees are in form, with two straight wins and strong showings under David Moyes. Villa, meanwhile, are still goalless after three games and desperately need to find attacking rhythm. With Jack Grealish returning to face his former side, expect fireworks, but with both teams near even in the odds, this one’s wide open.

7. Bournemouth vs Brighton

Brighton win, 30,9% · Draw, 26,7% · Bournemouth win, 42,4%

Bournemouth have surprised many with their strong start, including an impressive win at Tottenham. Brighton, however, enter this clash off a confidence boosting victory over Manchester City. This is the match most likely to end in a draw, and it's not hard to see why, both sides are energetic, unpredictable, and hungry to climb the table. It’s a coastal clash with more than three points on the line.

6. Fulham vs Leeds United

Fulham win, 56,6% · Draw, 22,4% · Leeds win, 21,0%

Fulham are looking for their first win of the season after a narrow and controversial loss to Chelsea. History looms, no team has ever conceded a penalty in six straight Premier League games, Fulham could be the first. Leeds come into this fixture with optimism, but Craven Cottage is rarely a kind venue for visitors. Expect goals though, their last four top flight meetings have produced 18.

5. Newcastle United vs Wolves

Newcastle win, 64,9% · Draw, 18,9% · Wolves win, 16,2%

Newcastle are firm favorites at St. James' Park, even without Alexander Isak, who departed for Liverpool. Enter Nick Woltemade and Yoane Wissa, both could make their debuts and are expected to help carry the Magpies' attacking load. Wolves, meanwhile, are still looking for their first point of the season. Newcastle have faced the fewest shots in the league so far, expect a dominant performance at home.

4. Manchester City vs Manchester United

Man City win, 65,6% · Draw, 18,6% · Man United win, 15,8%

The Manchester Derby always delivers, and this one feels especially crucial. City are coming off two losses, but the supercomputer still strongly favors Pep Guardiola’s side. New signings Gianluigi Donnarumma and Senne Lammens could make their debuts in goal, adding a twist to an already high stakes clash. United, despite winning last weekend, haven’t been convincing. Can they shock the Etihad and spoil City’s bounce back hopes?

3. Arsenal vs Nottingham Forest

Arsenal win, 66,9% · Draw, 18,1% · Forest win, 15,0%

Ange Postecoglou makes his Forest debut against none other than his old North London rivals. Arsenal are heavily backed to win this one, and with Forest having lost their last six away games to the Gunners by an aggregate of 19,2, the odds are justified. Still, Postecoglou is known for turning teams around quickly. Can he pull off a statement result in enemy territory?

2. Burnley vs Liverpool

Liverpool win, 69,0% · Draw, 17,1% · Burnley win, 13,9%

Liverpool have been perfect so far this season, and they’ve dominated Burnley in past meetings. The Reds have won their last six league visits to Turf Moor, and Burnley have managed just one win in their last 11 against reigning champions. Alexander Isak could debut here after his record breaking transfer, joining Ekitike and Ngumoha as potential debut scorers. This looks like a mismatch on paper.

1. Crystal Palace vs Sunderland

Crystal Palace win, 71,6% · Draw, 16,3% · Sunderland win, 12,1%

Palace are the supercomputer’s most confident pick this week, and for good reason. Unbeaten in their last nine league games, they’re playing with swagger and composure. Sunderland, while off to a surprisingly good start for a promoted side, will face their biggest test yet at Selhurst Park. Oliver Glasner’s side are flying, and this could be the weekend they break into the top four conversation.